Description
Human Osteoprotegerin / TNFRSF11B Protein, Fc Tag | TNB-H5259-1mg| Gentaur Distribution US, UK & Europe
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG). TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Source: Human Osteoprotegerin, Fc Tag (TNB-H5259) is expressed from human 293 cells (HEK293). It contains AA Glu 22 - Leu 401 (Accession # NP_002537).
Format: Powder.
Tag: C-Fc.
Expression System: HEK293.
Expression Region: Glu 22 - Leu 401.
Conjugate: Unconjugated.
Molecular Weight: 70.2 kDa.
Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 70.2 kDa. The protein migrates as 90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 92%.
Buffer: 50 mM Tris, 100 mM Glycine, pH7.5.
Storage Conditions: -20℃.
Shipping Conditions: RT
