Description
Human NPTX2 Protein, His Tag (MALS verified) | NP2-H52H6-1mg| Gentaur Distribution US, UK & Europe
Neuronal Pentraxin 2 (NPTX2), also named neuronal activity-regulated pentraxin, is a secreted glycoprotein characterized by a cyclic multimeric structure. In vivo, NTPX2 exerts various neurological effects by combining with the transmembrane protein neuronal pen traxin receptor (NPTXR). NPTX2 was thought to play a vital role in transmitting neurotrans mitters and maintaining synaptic plasticity. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) -type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD.
Source: Human NPTX2, His Tag (NP2-H52H6) is expressed from human 293 cells (HEK293). It contains AA Gly 16 - Leu 431 (Accession # P47972).
Format: Powder.
Tag: C-10ÃÂHis.
Expression System: HEK293.
Expression Region: Gly 16 - Leu 431.
Conjugate: Unconjugated.
Molecular Weight: 47.7 kDa.
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 47.7 kDa. The protein migrates as 50-63 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 95%.
Buffer: PBS, pH7.4.
Storage Conditions: -20âÂÂ.
Shipping Conditions: RT
