Human NOTCH1 Protein, Fc Tag (MALS verified) | NO1-H5255-1mg

Human NOTCH1 Protein, Fc Tag (MALS verified) | NO1-H5255-1mg| Gentaur Distribution US, UK & Europe

NOTCH1 Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The NOTCH1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.

Source: Human NOTCH1, Fc Tag (NO1-H5255) is expressed from human 293 cells (HEK293). It contains AA Ala 19 - Gln 526 (Accession # P46531-1).

Format: Powder.

Tag: C-Fc.

Expression System: HEK293.

Expression Region: Ala 19 - Gln 526.

Conjugate: Unconjugated.

Molecular Weight: 80.0 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 80.0 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT