Description
Human Netrin receptor DCC / DCC Protein, Fc Tag (MALS verified) | NEC-H5254-1mg| Gentaur Distribution US, UK & Europe
Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
Source: Human Netrin receptor DCC, Fc Tag (NEC-H5254) is expressed from human 293 cells (HEK293). It contains AA Phe 32 - Asn 1097 (Accession # P43146-1).
Format: Powder.
Tag: C-Fc.
Expression System: HEK293.
Expression Region: Phe 32 - Asn 1097.
Conjugate: Unconjugated.
Molecular Weight: 144.1 kDa.
Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 144.1 kDa. The protein migrates as 140-160 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 90%.
Buffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5.
Storage Conditions: -20℃.
Shipping Conditions: RT
