Description
Human Netrin-1 Protein, His Tag | NE1-H52H3-1mg| Gentaur Distribution US, UK & Europe
Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Involved in dorsal root ganglion axon projection towards the spinal cord. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
Source: Human Netrin-1, His Tag (NE1-H52H3) is expressed from human 293 cells (HEK293). It contains AA Val 22 - Ala 604 (Accession # O95631-1).
Format: Powder.
Tag: C-10×His.
Expression System: HEK293.
Expression Region: Val 22 - Ala 604.
Conjugate: Unconjugated.
Molecular Weight: 67.5 kDa.
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 67.5 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 95%.
Buffer: PBS, pH7.4 with NaCl.
Storage Conditions: -20℃.
Shipping Conditions: RT
