Human Mucin-1 / MUC-1 (890-1158) Protein, His Tag | MU1-H52H9-1mg

Human Mucin-1 / MUC-1 (890-1158) Protein, His Tag | MU1-H52H9-1mg| Gentaur Distribution US, UK & Europe

Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Probably plays a role in maintaining homeostasis on mucosal surfaces.

Source: Human Mucin-1 (890-1158), His Tag (MU1-H52H9) is expressed from human 293 cells (HEK293). It contains AA Ser 890 - Gly 1158 (Accession # P15941-1).

Format: Powder.

Tag: C-10×His.

Expression System: HEK293.

Expression Region: Ser 890 - Gly 1158.

Conjugate: Unconjugated.

Molecular Weight: 21.3 kDa (partial α chain) & 8.4 kDa (partial β chain).

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The mature form of Mucin-1 is a non-covalent heterodimeric complex with the proteolytically cleaved partial α and partial β chain. Each partial α and partial β chain has a calculated MW of 21.3 kDa (partial α chain) and 8.4 kDa (partial β chain). The protein migrates as 45-80 kDa (partial α chain) and 10 kDa (partial β chain) under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT