Description
Human Mesothelin - CHO-K1 Recombinant Cell Line | 78132 | Gentaur US, UK & Europe Disrtribition
Category: CAR-T/Cell Line
Application: Useful as MSLN-expressing target cells in co-culture assays with MSLN CAR-T cells and for screening other MSLN-binding molecules.
Background: Mesothelin (MSLN) is a glycophosphatidylinositol (GPI) linked cell-surface protein that is produced as a ~70 kDa precursor protein and cleaved by Furin protease to generate the ~40 kDa mature form. MSLN is frequently over-expressed in mesothelioma, ovarian, pancreatic, and non-small cell lung cancers, while its expression in normal tissues is restricted to the mesothelial lining. MSLN is a tumor-associated antigen and has been an attractive target for targeted immunotherapy approaches, including drug-conjugated antibodies and chimeric antigen receptor T-cells (CAR-T Cells).
Description: Recombinant CHO-K1 cells expressing cleaved, mature human Mesothelin (MSLN) gene (GenBank Accession #NM_005823.5) under the control of cytomegalovirus (CMV) promoter. This cell line was generated by limited dilution and isolation of individual clones, which were screened based on MSLN expression to obtain a high-expressing cell line.
Product Type: Cell Line
Shippement Condition: -80°C
