Human MERTK / Mer Protein, Fc Tag | MEK-H5253-1mg

Human MERTK / Mer Protein, Fc Tag | MEK-H5253-1mg| Gentaur Distribution US, UK & Europe

Tyrosine-protein kinase Mer (MERTK) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs) -mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Source: Human MERTK, Fc Tag (MEK-H5253) is expressed from human 293 cells (HEK293). It contains AA Ala 21 - Ile 505 (Accession # Q12866-1).

Format: Powder.

Tag: C-Fc.

Expression System: HEK293.

Expression Region: Ala 21 - Ile 505.

Conjugate: Unconjugated.

Molecular Weight: 79.1 Kda.

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 79.1 Kda. The protein migrates as 100-150 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT