Description
Human MANF Protein, His Tag (MALS verified) | MAF-H52H3-50ug| Gentaur Distribution US, UK & Europe
MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote the survival, growth and function of dopamine-specific neurons. MANF and its structural homolog CDNF each contain a N-terminal, saposin-like, lipid-binding domain, and a carboxyl-terminal domain that is not homologous to previously characterized protein structures. MANF and CDNF can prevent 6-OHDA-induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson's disease. Recombinant Human MANF is an 18.1 kDa protein consisting of 158 amino acids, including 8 cysteine residues.
Source: Human MANF Protein, His Tag (MAF-H52H3) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Leu 182 (Accession # P55145).
Format: Powder.
Tag: C-10×His.
Expression System: HEK293.
Expression Region: Leu 25 - Leu 182.
Conjugate: Unconjugated.
Molecular Weight: 20.0 kDa.
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 20.0 kDa. The protein migrates as 19-21 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 95%.
Buffer: PBS, pH7.4.
Storage Conditions: -20℃.
Shipping Conditions: RT
