Description
Human LRRC32 / GARP / Garpin Protein, Fc Tag | LR2-H5256-100ug| Gentaur Distribution US, UK & Europe
Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naïve T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naïve T cell proliferation.
Source: Human LRRC32, Fc Tag (LR2-H5256) is expressed from human 293 cells (HEK293). It contains AA His 20 - Asn 627 (Accession # Q14392-1).
Format: Powder.
Tag: C-Fc.
Expression System: HEK293.
Expression Region: His 20 - Asn 627.
Conjugate: Unconjugated.
Molecular Weight: 92.4 kDa.
Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 92.4 kDa. The protein migrates as 105 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 95%.
Buffer: Tris with Glycine, Arginine and NaCl, pH7.5.
Storage Conditions: -20℃.
Shipping Conditions: RT
