Description
Human LIGHT / TNFSF14 Protein, Mouse IgG2a Fc Tag, low endotoxin | LIT-H5256-1mg| Gentaur Distribution US, UK & Europe
Tumor necrosis factor ligand superfamily member 14 (LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR). LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.
Source: Human LIGHT, Mouse IgG2a Fc Tag, low endotoxin (LIT-H5256) is expressed from human 293 cells (HEK293). It contains AA Asp 74 - Val 240 (Accession # O43557-1).
Format: Powder.
Tag: N-mFc (mIgG2a).
Expression System: HEK293.
Expression Region: Asp 74 - Val 240.
Conjugate: Unconjugated.
Molecular Weight: 45.1 kDa.
Characteristics: This protein carries a mouse IgG2a Fc tag at the N-terminus. The protein has a calculated MW of 45.1 kDa. The protein migrates as 50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 95%.
Buffer: Tris with Glycine, Arginine and NaCl, pH7.5.
Storage Conditions: -20℃.
Shipping Conditions: RT
