Human LAMP5 / BAD-LAMP Protein, His Tag | LA5-H52H9-500ug

Human LAMP5 / BAD-LAMP Protein, His Tag | LA5-H52H9-500ug| Gentaur Distribution US, UK & Europe

LAMPs (lysosome associated membrane proteins) represent a family of glycosylated proteins present predominantly on the membrane of lysosomes whose expression can vary among different tissues, suggesting a separation of functions. LAMP5 is expressed highly and specifically in MLL-r leukemia. LAMP5 is a direct target of the oncogenic MLL-fusion protein. LAMP5 depletion significantly inhibited leukemia cell growth in vitro and in vivo. Functional studies showed that LAMP-5 is a novel modulator of innateimmune pathways in MLL-r leukemias. Downregulation of LAMP5 led to inhibition of NF-κB signaling and increased activation of type-1 interferon signaling downstream of Toll-like Receptor/Interleukin 1 Receptor activation.

Source: Human LAMP5, His Tag (LA5-H52H9) is expressed from human 293 cells (HEK293). It contains AA Glu 30 - Glu 235 (Accession # Q9UJQ1-1).

Format: Powder.

Tag: C-10×His.

Expression System: HEK293.

Expression Region: Glu 30 - Glu 235.

Conjugate: Unconjugated.

Molecular Weight: 25 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25 kDa. The protein migrates as 31-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT