Description
Human Laminin 511 E8 Protein, Fc Tag, premium grade | LA8-H5283-100ug| Gentaur Distribution US, UK & Europe
Laminin 511 E8 is a truncated laminin 511, which is one of the ECM proteins. laminin E8s serve as functionally minimal forms that retain the full capability for binding to integrins. Laminin 511-E8 consists of the C-terminal end of the alpha 5, beta 1, and gamma 1 chains. The laminin-511 heterotrimer (α5β1γ1) is one of the isoforms to be identified and a potent adhesive and pro-migratory substrate for a variety of normal and tumor cell lines in vitro. Previous studies indicated that laminin-511 contributes to tumor dissemination and metastasis in advanced breast carcinomas and other tumor types. Additionally, latest research uncovered that Laminin 511 might be a target antigen and involved in autoimmune pancreatitis.
Source: Human Laminin 511 E8 Protein, Fc Tag, premium grade (LA8-H5283) is expressed from human 293 cells (HEK293). It contains AA Glu 2655 - Ala 3327 (Laminin alpha5E8) & Asp 1714 - Leu 1786 (Laminin beta1E8) & Asp 1528 - Pro 1609 (Laminin gamma1E8) (Accession # O15230-1 (Laminin alpha5E8) & P07942-1 (Laminin beta1E8) & P11047-1 (Laminin gamma1E8) ).
Format: Powder.
Tag: N-Fc.
Expression System: HEK293.
Expression Region: Glu 2655 - Ala 3327 (Laminin alpha5E8) & Asp 1714 - Leu 1786 (Laminin beta1E8) & Asp 1528 - Pro 1609 (Laminin gamma1E8).
Conjugate: Unconjugated.
Molecular Weight: 76.7 kDa & 35.0 kDa & 35.7 kDa.
Characteristics: Human Laminin 511 E8 Protein, Fc Tag, premium grade, produced by co-expression of Laminin alpha5E8, Laminin beta1E8 and Laminin gamma1E8, has a calculated MW of 76.7 kDa, 35.0 kDa and 35.7 kDa. The non-reducing (NR) protein migrates as 45 kDa (subunit Laminin beta1E8 and subunit Laminin gamma1E8) and 100 kDa (subunit Laminin alpha5E8) respectively due to glycosylation.
Purity: 90%.
Buffer: 51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5.
Storage Conditions: -20℃.
Shipping Conditions: RT
