Description
Human Laminin 221 E8 Protein, Fc Tag, premium grade | LA2-H5269-1mg| Gentaur Distribution US, UK & Europe
Laminin-221 (LM221) takes multiple roles as a scaffold to store cells, growth factors and cytokines and is the most likely expressed cardiac laminin that maintains physiological activities of myocytes. Laminin 221-E8 consists of the C-terminal end of the alpha 2, beta 2, and gamma 1 chains. Previous study has confirmed that the laminin-221 heterotrimer (α2β2γ1) could bind integrin α7X1 and α7X2. Latest research indicated that the administration of LM221 enhanced accumulation of smooth muscle actin (SMA) and isolectin B4 (ILB4) double-positive cells to the damaged area and contributed to the improvement of cardiac function.
Source: Human Laminin 221 E8 Protein, Fc Tag, premium grade (LA2-H5269) is expressed from human 293 cells (HEK293). It contains AA Leu 1900 - Ala 2722 (Laminin alpha2E8) & Leu 1573 - Gln 1798 (Laminin beta2E8) & Asn1364 - Pro1609 (Laminin gamma1E8) (Accession # P24043-1 (Laminin alpha2E8) & P55268-1 (Laminin beta2E8) & P11047-1 (Laminin gamma1E8) ).
Format: Powder.
Tag: N-Fc.
Expression System: HEK293.
Expression Region: Leu 1900 - Ala 2722 (Laminin alpha2E8) & Leu 1573 - Gln 1798 (Laminin beta2E8) & Asn1364 - Pro1609 (Laminin gamma1E8).
Conjugate: Unconjugated.
Molecular Weight: 94.3 kDa (Laminin alpha2E8) & 51.3 kDa (Laminin beta2E8) & 53.7 kDa (Laminin gamma1E8).
Characteristics: Human Laminin 221 E8 Protein, Fc Tag, premium grade, produced by co-expression of Laminin alpha2E8, Laminin beta2E8 and Laminin gamma1E8, has a calculated MW of 94.3 kDa, 51.3 kDa and 53.7 kDa. The non-reducing (NR) protein migrates as 118-133 kDa due to glycosylation.
Purity: 90%.
Buffer: 51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5.
Storage Conditions: -20℃.
Shipping Conditions: RT
