Description
Human KIR2DL4 / CD158d Protein, Fc Tag | KI4-H5255-1mg| Gentaur Distribution US, UK & Europe
Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4), which belongs to the immunoglobulin superfamily, is an inhibitory receptor of NK cells. Soluble HLA-G binds to KIR2DL4 in endosomes and activates the pathway of DNA-PKcs (DNA-dependent protein kinase, catalytic subunit) -AKT-NF-κB signals. The stimulation of the ITIM of KIR2DL4 protein brings about the recruitment and activation of non-receptor protein phosphatases Src homology 2 domain-containing tyrosine phosphatase (SHP) -1 and SHP-2, and the following inhibition of CD16/FcγRIIIa signaling pathway in human NK cells.
Source: Human KIR2DL4, Fc Tag (KI4-H5255) is expressed from human 293 cells (HEK293). It contains AA His 24 - His 242 (Accession # Q99706-1).
Format: Powder.
Tag: C-Fc.
Expression System: HEK293.
Expression Region: His 24 - His 242.
Conjugate: Unconjugated.
Molecular Weight: 50.5 kDa.
Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.5 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 90%.
Buffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5.
Storage Conditions: -20℃.
Shipping Conditions: RT
