Description
Human JAK1 Protein, His Tag | JA1-H5547-50ug| Gentaur Distribution US, UK & Europe
JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body.
Source: Human JAK1, His Tag (JA1-H5547) is expressed from Baculovirus-Insect cells. It contains AA Ala 561 - Asn 852 (Accession # P23458-1).
Format: Liquid.
Tag: N-10×His.
Expression System: InsectCells.
Expression Region: Ala 561 - Asn 852.
Conjugate: Unconjugated.
Molecular Weight: 35.7 kDa.
Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 35.7 kDa. The protein migrates as 30-33 kDa under reducing (R) condition (SDS-PAGE).
Purity: 95%.
Buffer: 50 mM Tris, 500 mM NaCl, 2 mM TCEP, pH8.0.
Storage Conditions: -70℃.
Shipping Conditions: Dry ice
