Human Integrin isoform alpha-7X2B beta 1 (ITGA7X2B&ITGB1) Heterodimer Protein, His Tag&Tag Free | IT1-H52W8-100ug

Human Integrin isoform alpha-7X2B beta 1 (ITGA7X2B&ITGB1) Heterodimer Protein, His Tag&Tag Free | IT1-H52W8-100ug| Gentaur Distribution US, UK & Europe

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers, which is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). ITGA7 has been shown to interact with Merosin, ITGB1, FHL2 and FHL3.

Source: Human ITGA7X2B&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-H52W8) is expressed from human 293 cells (HEK293). It contains AA Phe 34 - Trp 1038 (ITGA7X2B) & Gln 21 - Asp 728 (ITGB1) (Accession # Q13683-7 (ITGA7X2B) & P05556-1 (ITGB1) ).

Format: Powder.

Tag: C-10×His | Native.

Expression System: HEK293.

Expression Region: Phe 34 - Trp 1038 (ITGA7X2B) & Gln 21 - Asp 728 (ITGB1).

Conjugate: Unconjugated.

Molecular Weight: 116.5 kDa (ITGA7X2B) & 83.7 kDa (ITGB1).

Characteristics: Human ITGA7X2B&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA7X2B and ITGB1, has a calculated MW of 116.5 kDa (ITGA7X2B) and 83.7 kDa (ITGB1). Subunit ITGA7X2B is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The non-reducing (NR) protein migrates as 130-135 kDa (ITGA7X2B) and 100-125 kDa (ITGB1) respectively due to glycosylation.

Purity: 90%.

Buffer: 50 mM Tris, 150 mM NaCl, pH7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT