Description
Human Integrin alpha X beta 2 (ITGAX&ITGB2) Heterodimer Protein, His Tag&Tag Free | IT2-H52W3-1mg| Gentaur Distribution US, UK & Europe
The integrin αXβ2 takes a key role in host defense and functions as a receptor for the complement C3 cleavage product iC3b, fibrinogen, denatured proteins, and intercellular adhesion molecule (ICAM) -1. Integrin αXβ2 αXβ2 has a unique cellular distribution with expression on monocytes, macrophages, and the CD8− subsets of dendritic cells and involves in priming and regulation of the immune response.
Source: Human ITGAX&ITGB2 Heterodimer Protein, His Tag&Tag Free (IT2-H52W3) is expressed from human 293 cells (HEK293). It contains AA Phe 20 -Pro 1107 (ITGAX) & Gln 23 - Asn 700 (ITGB2) (Accession # P20702-1 (ITGAX) & P05107-1 (ITGB2) ).
Format: Powder.
Tag: C-10×His | Native.
Expression System: HEK293.
Expression Region: Phe 20 -Pro 1107 (ITGAX) & Gln 23 - Asn 700 (ITGB2).
Conjugate: Unconjugated.
Molecular Weight: 126.5 kDa | 80.2 kDa.
Characteristics: Human ITGAX&ITGB2 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAX and ITGB2, has a calculated MW of 126.5 kDa (ITGAX) and 80.2 kDa (ITGB2). Subunit ITGAX is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB2 contains no tag but a basic tail at the C-terminus. The protein migrates as 145 kDa (ITGAX) and 90 kDa (ITGB2) under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 95%.
Buffer: 50 mM Tris, 150 mM NaCl, pH7.5.
Storage Conditions: -20℃.
Shipping Conditions: RT
