Human Integrin alpha L beta 2 (ITGAL&ITGB2) Heterodimer Protein, His Tag&Tag Free | IT2-H53W3-1mg

Human Integrin alpha L beta 2 (ITGAL&ITGB2) Heterodimer Protein, His Tag&Tag Free | IT2-H53W3-1mg| Gentaur Distribution US, UK & Europe

Integrin alpha-L beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha L beta 2 is also a receptor for F11R (By similarity). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating the role in lymphopoiesis. Integrin alpha L beta 2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.

Source: Human ITGAL&ITGB2 Heterodimer Protein, His Tag&Tag Free (IT2-H53W3) is expressed from CHO cells. It contains AA Tyr 26 - Met 1089 (ITGAL) & Gln 23 - Asn 700 (ITGB2) (Accession # P20701-1 (ITGAL) & P05107-1 (ITGB2) ).

Format: Powder.

Tag: C-10×His | Native.

Expression System: CHO.

Expression Region: Tyr 26 - Met 1089 (ITGAL) & Gln 23 - Asn 700 (ITGB2).

Conjugate: Unconjugated.

Molecular Weight: 124.1 kDa | 80.2 kDa.

Characteristics: Human ITGAL&ITGB2 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAL and ITGB2, has a calculated MW of 124.1 kDa (ITGAL) & 80.2 kDa (ITGB2). Subunit ITGAL is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB2 contains no tag but a basic tail at the C-terminus. The protein migrates as 140-150 kDa (ITGAL) and 90-95 kDa (ITGB2) under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: 50 mM Tris, 150 mM NaCl, pH7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT