Human ILDR2 Protein, Fc Tag | IL2-H5259-100ug

Human ILDR2 Protein, Fc Tag | IL2-H5259-100ug| Gentaur Distribution US, UK & Europe

ILDR2 belongs to the immunoglobulin superfamily. May be involved in lipid homeostasis and ER stress pathways. ILDR2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells. Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and cancer.

Source: Human ILDR2, Fc Tag (IL2-H5259) is expressed from human 293 cells (HEK293). It contains AA Leu 21 - Glu 186 (Accession # Q71H61-1).

Format: Powder.

Tag: C-Fc.

Expression System: HEK293.

Expression Region: Leu 21 - Glu 186.

Conjugate: Unconjugated.

Molecular Weight: 45.1 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 45.1 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT