Human IL-3 R Beta / CD131 Protein, Fc Tag (MALS verified) | CD1-H5256-1mg

Human IL-3 R Beta / CD131 Protein, Fc Tag (MALS verified) | CD1-H5256-1mg| Gentaur Distribution US, UK & Europe

CD131- the common β Subunit, is a member of the type 1 cytokine receptor family. There are three major classes of heteroreceptor complexes, where the receptor complex utilises a common shared receptor subunit as a signal-transducing chain along with a cytokine specific subunit. These three classes include those which use gp130, those which use γc and those which use the common β subunit, βc (CD131). CD131 is shared by three of the “four-helical bundle” family of cytokines; IL-3, IL-5 and GM-CSF, and forms a receptor complex along with a cytokine specific α chain for each of these cytokines.Moreover, even though each of these cytokines have their own specific α subunit, the co-utilisation of CD131 suggests a common intra-cellular process of both unique and/or overlapping activities on expressing cells.

Source: Human CD131, Fc Tag (CD1-H5256) is expressed from human 293 cells (HEK293). It contains AA Trp 17 - Trp 443 (Accession # P32927-1).

Format: Powder.

Tag: C-Fc.

Expression System: HEK293.

Expression Region: Trp 17 - Trp 443.

Conjugate: Unconjugated.

Molecular Weight: 75.1 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 75.1 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: 51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT