Human IL-23 R Protein, Fc Tag | ILR-H5254-1mg

Human IL-23 R Protein, Fc Tag | ILR-H5254-1mg| Gentaur Distribution US, UK & Europe

Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

Source: Human IL-23 R, Fc Tag (ILR-H5254) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Gly 355 (Accession # Q5VWK5-1).

Format: Powder.

Tag: C-Fc.

Expression System: HEK293.

Expression Region: Gly 24 - Gly 355.

Conjugate: Unconjugated.

Molecular Weight: 64.5 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 64.5 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: Tris with Glycine,  Arginine and NaCl,  pH7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT