Human IL-23 alpha & IL-12 beta Heterodimer Protein, premium grade | ILB-H5219-20ug

Human IL-23 alpha & IL-12 beta Heterodimer Protein, premium grade | ILB-H5219-20ug| Gentaur Distribution US, UK & Europe

Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Source: Human IL-23A&IL-12B Heterodimer Protein, premium grade (ILB-H5219) is expressed from human 293 cells (HEK293). It contains AA Ile 23 - Ser 328 (IL-12B) & Arg 20 - Pro 189 (IL-23A) (Accession # P29460-1 (IL-12B) & Q9NPF7-1 (IL-23A) ).

Format: Powder.

Tag: Native.

Expression System: HEK293.

Expression Region: Ile 23 - Ser 328 (IL-12B) & Arg 20 - Pro 189 (IL-23A).

Conjugate: Unconjugated.

Molecular Weight: 55.0 kDa.

Characteristics: This protein carries no "tag". The protein has a calculated MW of 55.0 kDa. The protein migrates as 60-65 kDa and 116 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT