Human IL-21 Protein, Fc Tag | IL1-H5253-1mg

(No reviews yet) Write a Review
SKU:
716-IL1-H5253-1mg
Availability:
IN STOCK
Weight:
1.20 KGS
€3,184.00
Frequently bought together:

Description

Human IL-21 Protein, Fc Tag | IL1-H5253-1mg| Gentaur Distribution US, UK & Europe

Interleukin-21 (IL-21) is a secreted protein which belongs to the IL-15 / IL-21 family. Interleukin-21 / IL-21 belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL21R) and the common cytokine receptor gamma chain (gamma (C) ). Interleukin-21 / IL-21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. The IL-21R is widely distributed on lympho-haematopoietic cells. IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.

Source: Human IL-21, Fc Tag (IL1-H5253) is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Ser 162 (Accession # Q9HBE4-1).

Format: Powder.

Tag: C-Fc.

Expression System: HEK293.

Expression Region: Gln 30 - Ser 162.

Conjugate: Unconjugated.

Molecular Weight: 41.9 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 41.9 kDa. The protein migrates as 45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT

View AllClose

Additional Information

Size:
1 mg
View AllClose