Human IL-2 Protein, Fc Tag (MALS verified) | IL2-H5269-1mg

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SKU:
716-IL2-H5269-1mg
Availability:
IN STOCK
Weight:
1.20 KGS
€3,184.00
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Description

Human IL-2 Protein, Fc Tag (MALS verified) | IL2-H5269-1mg| Gentaur Distribution US, UK & Europe

Interleukin-2 (IL-2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotrophic hormone that is instrumental in the body's natural response to microbial infection and in discriminating between foreign (non-self) and self. IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity. Mature human IL-2 shares 56% and 66% aa sequence identity with mouse and rat IL-2, respectively. Human and mouse IL-2 exhibit crossspecies activity. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is also necessary during T cell development in the thymus for the maturation of a unique subset of T cells that are termed regulatory T cells (T-regs). After exiting from the thymus, T-Regs function to prevent other T cells from recognizing and reacting against "self antigens", which could result in "autoimmunity". T-Regs do so by preventing the responding cells from producing IL-2. Thus, IL-2 is required to discriminate between self and non-self, another one of the unique characteristics of the immune system.

Source: Human IL-2 Protein, Fc Tag (IL2-H5269) is expressed from human 293 cells (HEK293). It contains AA Ala 21 - Thr 153 (Accession # P60568-1).

Format: Powder.

Tag: N-Fc.

Expression System: HEK293.

Expression Region: Ala 21 - Thr 153.

Conjugate: Unconjugated.

Molecular Weight: 41.9 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 41.9 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT

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Additional Information

Size:
1 mg
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