Human IL-15 R alpha / CD215 Protein, Fc Tag (MALS verified) | ILA-H5253-1mg

Human IL-15 R alpha / CD215 Protein, Fc Tag (MALS verified) | ILA-H5253-1mg| Gentaur Distribution US, UK & Europe

IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL-15RA, also known as CD215, IL-15 R alpha, is a widely expressed 60 kDa transmembrane glycoprotein. High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. An interleukin (IL) -15 superagonist/IL-15 receptor α fusion complex (IL-15SA/IL-15RA; ALT-803) activates the IL-15 receptor on CD8 T cells and NK cells, and has shown significant anti-tumor. Signal transduction involves SYK. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.

Source: Human IL-15 R alpha, Fc Tag (ILA-H5253) is expressed from human 293 cells (HEK293). It contains AA Ile 31 - Thr 205 (Accession # Q13261-1).

Format: Powder.

Tag: C-Fc.

Expression System: HEK293.

Expression Region: Ile 31 - Thr 205.

Conjugate: Unconjugated.

Molecular Weight: 44.8 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 44.8 kDa. The protein migrates as 58-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT