Human IL-12 R beta 2 Protein, His Tag (MALS verified) | ILB-H52H6-100ug

Human IL-12 R beta 2 Protein, His Tag (MALS verified) | ILB-H52H6-100ug| Gentaur Distribution US, UK & Europe

The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. IL-12RB2 is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. IL-12B2 gene acts as tumor suppressor in human acute and chronic B-cell leukemias/lymphomas， IL-12R beta 2 directly restrains multiple myeloma cell growth, and targeting of IL-12 to tumor cells holds promise as new therapeutic strategy.

Source: Human IL-12 R beta 2, His Tag (ILB-H52H6) is expressed from human 293 cells (HEK293). It contains AA Lys 24 - Asn 622 (Accession # Q99665-1).

Format: Powder.

Tag: C-10×His.

Expression System: HEK293.

Expression Region: Lys 24 - Asn 622.

Conjugate: Unconjugated.

Molecular Weight: 70.0 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 70.0 kDa. The protein migrates as 66 kDa and 80-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT