Human IL-12 Protein, premium grade | IL2-H5210-50ug

Human IL-12 Protein, premium grade | IL2-H5210-50ug| Gentaur Distribution US, UK & Europe

IL-12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and natural killer  (NK) cells. These effects include inducing production of IFN-gamma and TNF by resting and activated T and NK cells, synergizing with other IFN-gamma  inducers at both the transcriptional and post-transcriptional levels. This interaction induces IFN-gamma  gene expression, enhancing the cytotoxic activity of resting NK and T cells, inducing and synergizing with IL-2 in the generation of lymphokine-activated killer  (LAK) cells, acting as a co-mitogen to stimulate proliferation of resting T cells, and inducing proliferation of activated T and NK cells. Current evidence indicates that IL‑12, produced by macrophages in response to infectious agents, is a central mediator of the cell‑mediated immune response by its actions on the development, proliferation, and activities of TH1 cells. In its role as the initiator of cell-mediated immunity, it has been suggested that IL-12 has therapeutic potential as a stimulator of cell-mediated immune responses to microbial pathogens, metastatic cancers, and viral infections such as AIDS.

Source: Human IL-12 Protein, premium grade (IL2-H5210) is expressed from human 293 cells (HEK293). It contains AA Ile 23 - Ser 328 & Arg 23 - Ser 219 (Accession # P29460-1 & P29459-1).

Format: Powder.

Tag: Native.

Expression System: HEK293.

Expression Region: Ile 23 - Ser 328 & Arg 23 - Ser 219.

Conjugate: Unconjugated.

Molecular Weight: 58.9 kDa.

Characteristics: This protein carries no "tag". The protein has a calculated MW of 58.9 kDa. The protein migrates as 65-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT