Human IgG2 Fc Protein, Tag Free (MALS & SPR verified) | IG2-H5206-1mg

Human IgG2 Fc Protein, Tag Free (MALS & SPR verified) | IG2-H5206-1mg| Gentaur Distribution US, UK & Europe

Immunoglobulin G2 (IgG2) is a member of many immunoglobulin G developed and secreted by effective B cells. In wake of cutting by pepsin, IgG is divided into two F (ab) s with one antigen binding site and a high conserved Fc segment. The Fc segment bears a highly conserved N-glycosylation site. There are two members of IgG2: IgG2a and IgG2b. It was found that IgG2a was superior to IgG1 in activating complement. The glycosylation of the circulating immunoglobulin-γ (IgG) antibody molecules changes in rheumatoid arthritis. Ig gamma-2 chain Fc region contains two constant regions of IgG2 H chain (CH2, CH3).

Source: Human IgG2 Fc, Tag Free (IG2-H5206) is expressed from human 293 cells (HEK293). It contains AA Glu 99 - Lys 326 (Accession # P01859-1).

Format: Powder.

Tag: Native.

Expression System: HEK293.

Expression Region: Glu 99 - Lys 326.

Conjugate: Unconjugated.

Molecular Weight: 25.7 kDa.

Characteristics: This protein carries no "tag". The protein has a calculated MW of 25.7 kDa. The protein migrates as 30-33 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT