Human IGF-II R Protein, His Tag | IGR-H52H3-100ug

Human IGF-II R Protein, His Tag | IGR-H52H3-100ug| Gentaur Distribution US, UK & Europe

IGF2R, also known as the cation-independent mannose-6-phosphate receptor, is found ubiquitously in human tissues with a truncated soluble form of the receptor present in the circulation. Full-length, 300-kDa, IGF2R comprises a large N-terminal extracellular region of 15 homologous domains, a single membrane-spanning region and a small cytoplasmic tail. In addition to IGF-II binding, major IGF2R functions include sorting newly synthesized lysosomal enzymes and endocytosis of extracellular lysosomal enzymes. To perform these disparate functions, the extracellular region contains binding sites for IGF-II and phosphomannosyl residues.

Source: Human IGF-II R Protein, His Tag (IGR-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ser 1510 - Phe 2108 (Accession # P11717).

Format: Powder.

Tag: C-10×His.

Expression System: HEK293.

Expression Region: Ser 1510 - Phe 2108.

Conjugate: Unconjugated.

Molecular Weight: 68 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 68 kDa. The protein migrates as 75-90 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT