Description
Human IFN-beta Protein, His Tag (MALS verified) | IFB-H52H3-1mg| Gentaur Distribution US, UK & Europe
Interferon beta (IFN beta) is type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins. IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity).
Source: Human IFN-beta Protein, His Tag (IFB-H52H3) is expressed from human 293 cells (HEK293). It contains AA Met 22 - Asn 187 (Accession # P01574).
Format: Powder.
Tag: C-10×His.
Expression System: HEK293.
Expression Region: Met 22 - Asn 187.
Conjugate: Unconjugated.
Molecular Weight: 21.9 kDa.
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.9 kDa. The protein migrates as 26-29 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 90%.
Buffer: PBS, pH7.4.
Storage Conditions: -20℃.
Shipping Conditions: RT
