Human HMGB1 Protein, Mouse IgG2a Fc Tag, low endotoxin | HM1-H5255-100ug

Human HMGB1 Protein, Mouse IgG2a Fc Tag, low endotoxin | HM1-H5255-100ug| Gentaur Distribution US, UK & Europe

High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. The mechanism of inflammation and damage is binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release. This positions HMGB1 at the intersection of sterile and infectious inflammatory responses. HMGB1 has been studied as a DNA vaccine adjuvant and a target for cancer therapy.

Source: Human HMGB1 Protein, Mouse IgG2a Fc Tag (HM1-H5255) is expressed from human 293 cells (HEK293). It contains AA Gly 2 - Glu 215 (Accession # P09429-1).

Format: Powder.

Tag: N-mFc (mIgG2a).

Expression System: HEK293.

Expression Region: Gly 2 - Glu 215.

Conjugate: Unconjugated.

Molecular Weight: 51.6 kDa.

Characteristics: This protein carries a mouse IgG2a Fc tag at the N-terminus. The protein has a calculated MW of 51.6 kDa. The protein migrates as 60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT