Human Growth Hormone R (GHR) Protein, Fc Tag | GHR-H5257-50ug

Human Growth Hormone R (GHR) Protein, Fc Tag | GHR-H5257-50ug| Gentaur Distribution US, UK & Europe

Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

Source: Human GHR, Fc Tag (GHR-H5257) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Tyr 264 (Accession # P10912).

Format: Powder.

Tag: C-Fc.

Expression System: HEK293.

Expression Region: Ala 27 - Tyr 264.

Conjugate: Unconjugated.

Molecular Weight: 54.3 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 54.3 kDa. As a result of glycosylation, the protein migrates as 66-85 kDa under reducing (R) condition, and 135-160 kDa under non-reducing (NR) condition (SDS-PAGE).

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT