Human GITR Ligand / TNFSF18 Protein, Fc Tag | GIL-H526a-50ug

Human GITR Ligand / TNFSF18 Protein, Fc Tag | GIL-H526a-50ug| Gentaur Distribution US, UK & Europe

Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS). TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells. TNFSF18 also mediates activation of NF-kappa-B.

Source: Human GITR Ligand, Fc Tag (GIL-H526a) is expressed from human 293 cells (HEK293). It contains AA Gln 50 - Ser 177 (Accession # AAH69319.1).

Format: Powder.

Tag: N-Fc.

Expression System: HEK293.

Expression Region: Gln 50 - Ser 177.

Conjugate: Unconjugated.

Molecular Weight: 41.5 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 41.5 kDa. The protein migrates as 45-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: 50 mM Tris, 100 mM Glycine, pH7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT