Human Frizzled-2 / FZD2 Protein, Fc Tag | FZ2-H5251-1mg

Human Frizzled-2 / FZD2 Protein, Fc Tag | FZ2-H5251-1mg| Gentaur Distribution US, UK & Europe

Frizzled-2 (FZD2) is also known as FzE2, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD2 contains one FZ (frizzled) domain. FZD2 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. The Lys-Thr-X-X-X-Trp motif of FZD2 interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.

Source: Human Frizzled-2, Fc Tag (FZ2-H5251) is expressed from human 293 cells (HEK293). It contains AA Gln 24 - Ser 156 (Accession # AAI13403).

Format: Powder.

Tag: C-Fc.

Expression System: HEK293.

Expression Region: Gln 24 - Ser 156.

Conjugate: Unconjugated.

Molecular Weight: 41.7 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 41.7 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: Tris with Glycine,  Arginine and NaCl,  pH7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT