Description
Human Erythropoietin-alpha | 90257-B | Gentaur US, UK & Europe Disrtribition
Category: Cytokine
Application: N/A
Background: EPO is predominantly synthesized and secreted by tubular and juxtatubular capillary endothelial and interstitial cells of the kidney. Approximately 10-15% of the total amount of Epo comes from extrarenal sources and is predominantly produced by hepatocytes and Kupffer cells of the liver. Approximately 40% of the molecular mass of Epo is due to its glycosylation. Glycosylation is an important factor determining the pharmacokinetic behavior of Epo in vivo. Non- glycosylated Epo has an extremely short biological half life. It still binds to its receptor and may even have a higher specific activity in vitro.
Description: Recombinant EPO-a is a glycosylated disulfide-linked homodimeric protein consisting of 166 amino acid residues, and migrates as an approximately 35 kDa protein under reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human EPO mature chain was expressed in Chinese Hamster Ovary (CHO) cells.
Product Type: Protein
Shippement Condition: -20°C or -80°C
