Description
Human EpCAM / TROP1 Protein, Llama IgG2b Fc Tag, low endotoxin | EPM-H5259-1mg| Gentaur Distribution US, UK & Europe
EpCAM is also known as CO171A, EGP, EGP40, GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A (mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.
Source: Human EpCAM, Llama IgG2b Fc Tag (EPM-H5259) is expressed from human 293 cells (HEK293). It contains AA Gln 24 - Lys 265 (Accession # AAH14785.1).
Format: Powder.
Tag: C-LlamaFc (LlamaIgG2b).
Expression System: HEK293.
Expression Region: Gln 24 - Lys 265.
Conjugate: Unconjugated.
Molecular Weight: 55.2 kDa.
Characteristics: This protein carries a llama IgG2b Fc tag at the C-terminus. The protein has a calculated MW of 55.2 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 95%.
Buffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5.
Storage Conditions: -20℃.
Shipping Conditions: RT
