Human EGFRvIII- CHO K1 Recombinant Cell Line (High or Low Expression)-78145-H | 78145-H

Human EGFRvIII- CHO K1 Recombinant Cell Line (High or Low Expression)-78145-H | 78145-H | Gentaur US, UK & Europe Disrtribition

Category: Kinase/Cell Line

Application: Screen for inhibitors of EGFRvIII signaling for immuno-oncology research and drug discovery.

Background: Background The epidermal growth factor receptor (EGFR, ErbB-1, HER1) belongs to a family of receptor tyrosine kinases that includes three other closely-related members (HER2, HER3 and HER4). EGFR gene amplification, mutation and re-arrangement are frequently observed in primary glioblastoma multiforme (GBM). The most common EGFR variant in GBM, EGFRvIII, is characterized by a deletion of 267 amino acids in the extracellular domain, leading to a receptor that is unable to bind ligand yet is constitutively active. EGFRvIII enhances the tumorigenic potential of GBM by activating and sustaining mitogenic, anti-apoptotic, and pro-invasive signaling pathways.

Description: Recombinant hEGFRvIII-CHO K1 cell line stably expressing full-length human EGFRvIII receptor (accession number NP_001333870). Surface expression of hEGFRvIII was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of hEGFRvIII expression (High and Low) to mimic different stages of cancer target cells with various EGFRvIII expression levels.

Product Type: Cell Line

Shippement Condition: -80°C