Description
Human E-Cadherin / Cadherin-1 (155-709) Protein, Fc Tag (MALS verified) | ECD-H5256-100ug| Gentaur Distribution US, UK & Europe
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-1 (CDH1) is also known as epithelial cadherin (E-cadherin), CD_antigen (CD324), Uvomorulin (UVO) ECAD and CDHE, CDH1 / CD324 contains 5 cadherin domains. CDH1 / CD324 / ECAD is expressed in non-neural epithelial tissues. CDH1 / E-CAD is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad promotes non-amyloidogenic degradation of Abeta precursors and has a strong inhibitory effect on APP C99 and C83 production. Defects in CDH1 / CD324 / ECAD are the cause of hereditary diffuse gastric cancer (HDGC).
Source: Human E-Cadherin (155-709) Protein, Fc Tag (ECD-H5256) is expressed from human 293 cells (HEK293). It contains AA Asp 155 - Ala 709 (Accession # P12830-1).
Format: Powder.
Tag: C-Fc.
Expression System: HEK293.
Expression Region: Asp 155 - Ala 709.
Conjugate: Unconjugated.
Molecular Weight: 87.0 kDa.
Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 87.0 kDa . The protein migrates as 50 kDa and 95-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 90%.
Buffer: 20 mM Tris, 150 mM NaCl, pH8.0.
Storage Conditions: -20℃.
Shipping Conditions: RT
