Description
Human / Cynomolgus / Rhesus macaque CD28 Protein, His Tag, active dimer (MALS verified) | CD8-H52Hc-100ug| Gentaur Distribution US, UK & Europe
T-cell-specific surface glycoprotein CD28 is also known as TP44, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
Source: Human / Cynomolgus / Rhesus macaque CD28, His Tag (CD8-H52Hc) is expressed from human 293 cells (HEK293). It contains AA Asn 19 - Pro 152 (Accession # P10747-1). In the region Asn 19 - Pro 152, the AA sequence of Human, Cynomolgus and Rhesus macaque CD28 are homologus.
Format: Powder.
Tag: C-10×His.
Expression System: HEK293.
Expression Region: Asn 19 - Pro 152.
Conjugate: Unconjugated.
Molecular Weight: 17.0 kDa.
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 17.0 kDa. As a result of glycosylation, the protein migrates as 30-42 kDa under reducing (R) condition, and 33-42 kDa and 60-66 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE).
Purity: 90%.
Buffer: PBS, pH7.4.
Storage Conditions: -20℃.
Shipping Conditions: RT
