Human CTGF / CCN2 Protein, Fc Tag | GTF-H5253-1mg

Human CTGF / CCN2 Protein, Fc Tag | GTF-H5253-1mg| Gentaur Distribution US, UK & Europe

Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.

Source: Human CTGF, Fc Tag (GTF-H5253) is expressed from human 293 cells (HEK293). It contains AA Gln27-Ala349 (Accession # Q5M8T4-1 ).

Format: Powder.

Tag: N-Fc.

Expression System: HEK293.

Expression Region: Gln27-Ala349.

Conjugate: Unconjugated.

Molecular Weight: 61.9 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 61.9 kDa. The protein migrates as 55-60 kDa and 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT