Human Complement C5a Protein, His Tag | C5A-H51H9-50ug

Human Complement C5a Protein, His Tag | C5A-H51H9-50ug| Gentaur Distribution US, UK & Europe

Complement Component C5a (C5a) is also known as C5, and is a protein fragment released from complement component C5., is a potent chemotactic factor for human peripheral blood neutrophils and monocytes, and is believed to play an important role in a number of inflammatory conditions. There are several functions in the below: C5a is an anaphylatoxin, causing the release of histamine from mast cells; C5a is effective leukocyte chemoattractants, causing the accumulation of white blood cells, especially neutrophil granulocytes, at sites of complement activation; C5a activates white blood cells by increasing avidity for white blood cell integrins and upregulating the Lipoxygenase pathway for arachidonic acid metabolism; C5a is a powerful inflammatory mediator, and seems to be a key factor in the development of pathology of many inflammatory diseases involving the complement system; C5a modulates balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing autoimmune response.

Source: Human Complement C5a, His Tag (C5A-H51H9) is expressed from E. coli cells. It contains AA Leu 679 - Arg 751 (Accession # P01031-1).

Format: Powder.

Tag: N-10×His.

Expression System: E. coli.

Expression Region: Leu 679 - Arg 751.

Conjugate: Unconjugated.

Molecular Weight: 10.2 kDa.

Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 10.2 kDa. The protein migrates as 14-15 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT