Description
Human CD74 / DHLAG Protein, Llama IgG2b Fc Tag, low endotoxin | CD4-H5258-1mg| Gentaur Distribution US, UK & Europe
Cluster of Differentiation 74 (CD74) is also known as HLA class II histocompatibility antigen gamma chain (HLADG), DHLAG, Ia-GAMMA, invariant chain (Abbreviated Ii). CD74 / HLADG is a polypeptide involved in the formation and transport of MHC class II protein. The cell surface form of the invariant chain is known as CD74. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation. CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha / beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal / lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 / DHLAG also serves as cell surface receptor for the cytokine MIF.
Source: Human CD74, Llama IgG2b Fc Tag, low endotoxin (CD4-H5258) is expressed from human 293 cells (HEK293). It contains AA Gln 73 - Met 232 (Accession # P04233-2).
Format: Powder.
Tag: N-LlamaFc (LlamaIgG2b).
Expression System: HEK293.
Expression Region: Gln 73 - Met 232.
Conjugate: Unconjugated.
Molecular Weight: 49.4 kDa.
Characteristics: This protein carries a llama IgG2b Fc tag at the N-terminus. The protein has a calculated MW of 49.4 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 95%.
Buffer: 50 mM Tris, 100mM Glycine, 25mM Arginine, 150mM NaC, pH7.5.
Storage Conditions: -20℃.
Shipping Conditions: RT
