Description
Human CD39 Protein, Mouse IgG2a Fc Tag (active enzyme) | CD9-H5253-25ug| Gentaur Distribution US, UK & Europe
CD39 is also known as Ectonucleoside triphosphate diphosphohydrolase 1, ENTPD1, NTPDase 1, Ecto-ATPDase 1, in the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. NTPDase-1 was originally described as CD39, a B lymphocyte cell surface marker, but it is also present on the surface of natural killer cells, T cells, and some endothelial cells.Regulatory T cells (Tregs) mediate immunosuppression through multiple, non-redundant, cell-contact dependent and independent mechanisms, a growing body of evidence suggests an important role for the CD39-CD73-adenosine pathway. CD39 ectonucleotidase is the rate-limiting enzyme of a cascade leading to the generation of suppressive adenosine that alters CD4 and CD8 T cell and natural killer cell antitumor activities.
Source: Human CD39, Mouse IgG2a Fc Tag (CD9-H5253) is expressed from human 293 cells (HEK293). It contains AA Thr 38 - Val 478 (Accession # P49961-1).
Format: Liquid.
Tag: C-mFc (mIgG2a).
Expression System: HEK293.
Expression Region: Thr 38 - Val 478.
Conjugate: Unconjugated.
Molecular Weight: 77.3 kDa.
Characteristics: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 77.3 kDa. The protein migrates as 95-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 95%.
Buffer: 20 mM Tris, 500 mM Argnine, 150 mM NaCl, pH7.5.
Storage Conditions: -70℃.
Shipping Conditions: Dry ice
