Human CD28H / IGPR-1 Protein, Fc Tag (MALS verified) | CDH-H5251-1mg

Human CD28H / IGPR-1 Protein, Fc Tag (MALS verified) | CDH-H5251-1mg| Gentaur Distribution US, UK & Europe

CD28 homolog (CD28H), also called transmembrane and immunoglobulin domain containing 2 (TMIGD2) and IGPR-1, is encoded by the TMIGD2 gene. CD28H is constitutively expressed on naive T and NK cells. After interaction of CD28 homolog with B7 homologue, the peripheral effector and memory T cells can be activated and proliferated by Akt-dependent signalling cascade. Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.

Source: Human CD28H, Fc Tag (CDH-H5251) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Gly 150 (Accession # AAH15655.1).

Format: Powder.

Tag: C-Fc.

Expression System: HEK293.

Expression Region: Leu 23 - Gly 150.

Conjugate: Unconjugated.

Molecular Weight: 40.6 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. As a result of glycosylation, the protein migrates as 50-60 kDa under reducing (R) condition, and 90-116 kDa under non-reducing (NR) condition (SDS-PAGE).

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT