Description
Human CD27 Ligand / CD70 Protein, Fc Tag, active trimer (MALS verified) | CDL-H5266-1mg| Gentaur Distribution US, UK & Europe
Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.
Source: Human CD27 Ligand Protein, Fc Tag (CDL-H5266) is expressed from human 293 cells (HEK293). It contains AA Ser 52 - Pro 193 (Accession # P32970-1) trimer Design.
Format: Powder.
Tag: N-Fc.
Expression System: HEK293.
Expression Region: Ser 52 - Pro 193.
Conjugate: Unconjugated.
Molecular Weight: 74.1 kDa.
Characteristics: This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 74.1 kDa. The protein migrates as 130-150 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Purity: 95%.
Buffer: Tris, Glycine and NaCl, pH7.5.
Storage Conditions: -20℃.
Shipping Conditions: RT
