Description
Human CBLB / RNF56 Protein, His Tag | CBB-H5148-1mg| Gentaur Distribution US, UK & Europe
Casitas B-lineage lymphoma proto-oncogene b (CBLB) is also known as RNF56. E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle.
Source: Human CBLB, His Tag (CBB-H5148) is expressed from E. coli cells. It contains AA Ala 39 - Phe 426 (Accession # Q13191-1).
Format: Powder.
Tag: N-10×His.
Expression System: E. coli.
Expression Region: Ala 39 - Phe 426.
Conjugate: Unconjugated.
Molecular Weight: 47.0 kDa.
Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 47.0 kDa. The protein migrates as 46 kDa under reducing (R) condition (SDS-PAGE).
Purity: 95%.
Buffer: 40 mM HEPES, 120 mM NaCl, pH7.5.
Storage Conditions: -20℃.
Shipping Conditions: RT
