Human beta Defensin-2 | 90107-A

Human beta Defensin-2 | 90107-A | Gentaur US, UK & Europe Disrtribition

Category: Cytokine

Application: N/A

Background: Defensins are a large family of peptides of which two groups exist in mammals: alpha defensins and beta defensins, which are distinguishable by the spacing and connectivity of the conserved cysteine residues within the mature peptides. It is thought that defensins function in the eradication of pathogens from the host system by inserting themselves into the bacterial membrane under the influence of membrane potential, forming channels which lead to leakage of cytoplasmic molecules and cell death. Unlike hBD-1, this second peptide, human beta-defensin-2 (hBD-2), is regulated at a transcriptional level in response to contact with microorganisms, and is highly effective in killing Gram negative bacteria. Its expression is also upregulated by the cytokine tumor necrosis factor-alpha.

Description: Recombinant beta Defensin-2 is a disulfide-linked monomer protein consisting of 42 amino acid residues, and migrates as an approximately 4 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human beta Defensin-2 mature chain was expressed in E. coli.

Product Type: Protein

Shippement Condition: gel packs or dry ice