Description
Human APRIL / TNFSF13 Protein, Fc Tag, active trimer | APL-H5263-1mg| Gentaur Distribution US, UK & Europe
APRIL (a proliferation-inducing ligand) is also known as Tumor necrosis factor ligand superfamily member 13, TALL-2, TRDL-1, CD256, TNFFSF 13, cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. APRIL is a cytokine of the tumor necrosis factor family associated mainly with hematologic malignancies. The closely related TNF family ligands B cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) serve in the generation and maintenance of mature B-lymphocytes. Both BAFF and APRIL assemble as homotrimers that bind and activate several receptors that they partially share. BAFF-APRIL heteromers of different stoichiometries have distinct receptor-binding properties and activities. In addition, expression of APRIL was regulated by miR-145 in GC cells.
Source: Human APRIL Protein, Fc Tag (APL-H5263) is expressed from human 293 cells (HEK293). It contains AA Gln 111 - Leu 250 (Accession # O75888-1).
Format: Powder.
Tag: N-Fc.
Expression System: HEK293.
Expression Region: Gln 111 - Leu 250.
Conjugate: Unconjugated.
Molecular Weight: 42.2 kDa.
Characteristics: This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 42.2 kDa. The protein migrates as 45-53 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 90%.
Buffer: PBS, 0.5M Arginine, pH7.4.
Storage Conditions: -20℃.
Shipping Conditions: RT
