Human APP / Abeta40 Protein, His Tag | APP-H51H7-500ug

Human APP / Abeta40 Protein, His Tag | APP-H51H7-500ug| Gentaur Distribution US, UK & Europe

Amyloid precursor protein (APP) is a type I integral membrane protein ubiquitously expressed in many tissues and concentrated in the synapses of neurons. It has three predominant splice variants: APP695, APP751, and APP770. The majority of APP is cleaved at the plasma membrane by the α-secretase in the non-amyloidogenic pathway. The amyloidogenic pathway starts with β-secretase cleavage by BACE1 on the N-terminal part of the Aβ domain, releasing sAPPβ from a membrane-anchored fragment named βCTF or C99, which is subsequently cleaved by γ-secretase to release Aβ.

Source: Human Abeta40, His Tag (APP-H51H7) is expressed from E.coli cells. It contains AA Asp 672 - Val 711 (Accession # P05067-1).

Format: Powder.

Tag: C-10×His.

Expression System: E. coli.

Expression Region: Asp 672 - Val 711.

Conjugate: Unconjugated.

Molecular Weight: 6.3 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 6.3 kDa. The protein migrates as 11 kDa under reducing (R) condition (SDS-PAGE).

Purity: 95%.

Buffer: PBS, 0.2 M Arginine, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT